p62 works as a hub modulation in the ageing process

p62 app  Here, we report that phosphorylation of autophagy-associated protein p62 by AMP-activated protein kinase drives ACD and mitophagy in HCN cells  β‑asarone modulates Beclin‑1, LC3 and p62 expression to attenuate Aβ40 and Aβ42 levels in APPPS1 transgenic mice with Alzheimer's disease

p62 is a scaffolding protein that interacts with various signaling molecules p62 contains an LC3-interacting region and is believed to be a substrate for p62 is recruited to the ER at an early-stage autophagosome formation independently of most Atg proteins

Here, we report that phosphorylation of autophagy-associated protein p62 by AMP-activated protein kinase drives ACD and mitophagy in HCN cells  p62 ΔPB1, mCherry p62 ΔPB1 ΔUBA, or mCherry p62 ΔPB1 S403E The neuroprotective role of Panax notoginseng saponins in APPPS1 transgenic mice