COOH-terminal fragment of APP interacts with p62, forms an

p62 app  p62SQSTM1 to modulate S et al Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin  Molecular Psychiatry 2016 TLDR It is shown that increasing brain p62 expression rescues cognitive deficits in APPPS1 mice, a widely used animal model of AD

Collectively, our data suggest that the downregulation of SEPTIN5 increases the autophagy-mediated degradation of APP CTFs, leading to reduced levels of Aβ in β‑asarone modulates Beclin‑1, LC3 and p62 expression to attenuate Aβ40 and Aβ42 levels in APPPS1 transgenic mice with Alzheimer's disease

Según los investigadores, el p62 es capaz de inhibir los mecanismos que reparan el ADN dañado APP EL TIEMPO Personaliza, descubre e informate App View largeDownload slide Identification of a p62 nucleolar localization signal A, The p62 sequence was submitted to NoD, a NoLS prediction program